Article
Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations.
American journal of respiratory and critical care medicine - 1 Jul 2005
Weiss Lauren A, Lester Lucille A, Gern James E, Wolf Raoul L, Parry Rodney, Lemanske Robert F, Solway Julian, Ober Carole
Abstract excerpt
RATIONALE: Recent genetic studies have implicated integrins in asthma and atopy susceptibility. We therefore evaluated the integrin-beta3 gene (ITGB3), an integrin gene within an asthma linkage peak on chromosome 17, as a candidate for susceptibility to asthma- and atopy-related phenotypes. METHODS AND MEASUREMENTS: We genotyped and performed association tests on 19 single nucleotide polymorphisms in ITGB3 in the...
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