Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic implication of a novel thiamine transporter in human hypertension.

Journal of the American College of Cardiology - 22 Apr 2014

Zhang Kuixing, Huentelman Matthew J, Rao Fangwen, Sun Eric I, Corneveaux Jason J, Schork Andrew J, Wei Zhiyun, Waalen Jill, Miramontes-Gonzalez Jose Pablo, Hightower C Makena, Maihofer Adam X, Mahata Manjula, Pastinen Tomi, Ehret Georg B, Schork Nicholas J, Eskin Eleazar, Nievergelt Caroline M, Saier Milton H, O'Connor Daniel T

Abstract excerpt

OBJECTIVES: This study coupled 2 strategies-trait extremes and genome-wide pooling-to discover a novel blood pressure (BP) locus that encodes a previously uncharacterized thiamine transporter. BACKGROUND: Hypertension is a heritable trait that remains the most potent and widespread cardiovascular risk factor, although details of its genetic determination are poorly understood. METHODS: Representative genomic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Blood Pressure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Hypertension

Share to Membrane Transport Proteins

Share to Polymorphism, Genetic

Share to Thiamine

Source

Open in PubMed Open full text

Identifiers

PMID: 24509276
DOI: 10.1016/j.jacc.2014.01.007
PMCID: PMC3992204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic implication of a novel thiamine transporter in human hypertension.PMID 24509276Read ↗

Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo.Semantic proximity Read ↗

Blood pressure loci identified with a gene-centric array.Semantic proximity Read ↗

Adrenergic polymorphism and the human stress response.Semantic proximity Read ↗

Genetic Determinants of Thiazide-Induced Hyperuricemia, Hyperglycemia, and Urinary Electrolyte Disturbances - A Genome-Wide Evaluation of the UK Biobank.Semantic proximity Read ↗

Pharmacoepigenetics of hypertension: genome-wide methylation analysis of responsiveness to four classes of antihypertensive drugs using a double-blind crossover study designSemantic proximity Read ↗

Genome-wide association studies will unlock the genetic basis of hypertension: pro side of the argument.Semantic proximity Read ↗

Whole Transcriptome Sequencing Analyses Reveal Molecular Markers of Blood Pressure Response to Thiazide Diuretics.Semantic proximity Read ↗

From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.Semantic proximity Read ↗

Prediction and Subtyping of Hypertension from Pan-Tissue Transcriptomic and Genetic Analyses.Semantic proximity Read ↗

Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure.Semantic proximity Read ↗

Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion.Semantic proximity Read ↗

Human tyrosine hydroxylase natural allelic variation: influence on autonomic function and hypertension.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.