The Gain-of-Function Integrin β3 Pro33 Variant Alters the Serotonin System in the Mouse Brain.

doi:10.1523/JNEUROSCI.1482-17.2017

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Article

The Gain-of-Function Integrin β3 Pro33 Variant Alters the Serotonin System in the Mouse Brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Nov 2017

Dohn Michael R, Kooker Christopher G, Bastarache Lisa, Jessen Tammy, Rinaldi Capria, Varney Seth, Mazalouskas Matthew D, Pan Hope, Oliver Kendra H, Velez Edwards Digna R, Sutcliffe James S, Denny Joshua C, Carneiro Ana M D

Abstract excerpt

Engagement of integrins by the extracellular matrix initiates signaling cascades that drive a variety of cellular functions, including neuronal migration and axonal pathfinding in the brain. Multiple lines of evidence link the ITGB3 gene encoding the integrin β3 subunit with the serotonin (5-HT) system, likely via its modulation of the 5-HT transporter (SERT). The ITGB3 coding polymorphism Leu33Pro (rs5918, PlA2)...

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Identifiers

PMID: 29038237
DOI: 10.1523/JNEUROSCI.1482-17.2017
PMCID: PMC5688530

Genes

ITGB3

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