Article
Helicobacter pylori CagA containing ITAM-like sequences localized to lipid rafts negatively regulates VacA-induced signaling in vivo.
Helicobacter - 1 Feb 2003
Asahi Momoyo, Tanaka Yukie, Izumi Toshimasa, Ito Yoshiyuki, Naiki Hironobu, Kersulyte Dangeruta, Tsujikawa Kazutake, Saito Masakazu, Sada Kiyonao, Yanagi Shigeru, Fujikawa Akihiro, Noda Masaharu, Itokawa Yoshinori
Abstract excerpt
BACKGROUND: Helicobacter pylori CagA is injected into the host cell and tyrosine-phosphorylated. We examined tyrosine-phosphorylation sites of CagA, as well as the function of CagA proteins in vivo and in vitro. METHODS: After proteolytic digestion of CagA with lysyl endopeptidase, CagA tyrosine-...
Topics
- Amino Acid Sequence
- Antigens, Bacterial
- Bacterial Proteins
- Binding Sites
- Cell Line
- Gastric Mucosa
- Genes, Bacterial
- Helicobacter Infections
- Helicobacter pylori
- Humans
- Immunohistochemistry
- Mass Spectrometry
- Membrane Microdomains