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Article

COMT Val158Met genotype influences neurodegeneration within dopamine-innervated brain structures.

Neurology - 22 May 2012

Gennatas E D, Cholfin J A, Zhou J, Crawford R K, Sasaki D A, Karydas A, Boxer A L, Bonasera S J, Rankin K P, Gorno-Tempini M L, Rosen H J, Kramer J H, Weiner M, Miller B L, Seeley W W

Abstract excerpt

OBJECTIVE: We sought to determine whether the Val(158)Met polymorphism in the catechol-O-methyltransferase (COMT) gene influences neurodegeneration within dopamine-innervated brain regions. METHODS: A total of 252 subjects, including healthy controls and patients with Alzheimer disease, behavioral variant frontotemporal dementia, and semantic dementia, underwent COMT genotyping and structural MRI. RESULTS:...

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Source

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Identifiers

PMID: 22573634
DOI: 10.1212/WNL.0b013e3182574fa1
PMCID: PMC3359506

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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