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Article

Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations.

The Journal of biological chemistry - 3 Jun 2005

Norris Erin H, Giasson Benoit I, Hodara Roberto, Xu Shaohua, Trojanowski John Q, Ischiropoulos Harry, Lee Virginia M-Y

Abstract excerpt

Previous studies demonstrated that alpha-synuclein (alpha-syn) fibrillization is inhibited by dopamine, and studies to understand the molecular basis of this process were conducted (Conway, K. A., Rochet, J. C., Bieganski, R. M., and Lansbury, P. T., Jr. (2001) Science 294, 1346-1349). Dopamine inhibition of alpha-syn fibrillization generated exclusively spherical oligomers that depended on dopamine autoxidation...

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PMID: 15817478
DOI: 10.1074/jbc.M412621200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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