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Article

Tyrosine-to-cysteine modification of human alpha-synuclein enhances protein aggregation and cellular toxicity.

The Journal of biological chemistry - 12 Mar 2004

Zhou Wenbo, Freed Curt R

Abstract excerpt

The deposition of alpha-synuclein and other cellular proteins in Lewy bodies in midbrain dopamine neurons is a pathological hallmark of Parkinson's disease. Nitrative and oxidative stress can induce alpha-synuclein protein aggregation, possibly initiated by the formation of stable cross-linking dimers. To determine whether enhanced dimer formation can accelerate protein aggregation and increase cellular toxicity,...

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PMID: 14699135
DOI: 10.1074/jbc.M307563200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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