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Article

Dopamine affects the stability, hydration, and packing of protofibrils and fibrils of the wild type and variants of alpha-synuclein.

Biochemistry - 16 Jan 2007

Follmer Cristian, Romão Luciana, Einsiedler Carla M, Porto Thaís C R, Lara Flávio Alves, Moncores Marlos, Weissmüller Gilberto, Lashuel Hilal A, Lansbury Peter, Neto Vivaldo Moura, Silva Jerson L, Foguel Debora

Abstract excerpt

Parkinson's disease (PD) is characterized by the presence of cytoplasmic inclusions composed of alpha-synuclein (alpha-syn) in dopaminergic neurons. This suggests a pivotal role of dopamine (DA) on PD development. Here, we show that DA modulates differently the stability of protofibrils (PF) and fibrils (F) composed of wild type or variants of alpha-syn (A30P and A53T) as probed by high hydrostatic pressure...

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PMID: 17209557
DOI: 10.1021/bi061871+

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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