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Article

Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds.

FEBS letters - 20 Apr 2011

Caruana Mario, Högen Tobias, Levin Johannes, Hillmer Andreas, Giese Armin, Vassallo Neville

Abstract excerpt

Aggregation of alpha-synuclein (αS) into oligomers is critically involved in the pathogenesis of Parkinson's disease (PD). Using confocal single-molecule fluorescence spectroscopy, we have studied the effects of 14 naturally-occurring polyphenolic compounds and black tea extract on αS oligomer formation. We found that a selected group of polyphenols exhibited potent dose-dependent inhibitory activity on αS...

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PMID: 21443877
DOI: 10.1016/j.febslet.2011.03.046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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