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Article

A peptide motif consisting of glycine, alanine, and valine is required for the fibrillization and cytotoxicity of human alpha-synuclein.

Biochemistry - 29 Jul 2003

Du Hai-Ning, Tang Lin, Luo Xiao-Ying, Li Hong-Tao, Hu Jun, Zhou Jia-Wei, Hu Hong-Yu

Abstract excerpt

Amyloid-like aggregation or fibrillization of alpha-synuclein (alpha-Syn) and the filamentous deposits in Lewy bodies are believed to be closely associated with several fatal neurodegenerative disorders, including Parkinson's disease and Alzheimer's disease. Here, we report the importance of a ni...

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Identifiers

PMID: 12873148
DOI: 10.1021/bi034028+

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12873148-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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