Article
G209A mutant alpha synuclein expression specifically enhances dopamine induced oxidative damage.
Neurochemistry international - 1 Oct 2004
Orth M, Tabrizi S J, Tomlinson C, Messmer K, Korlipara L V P, Schapira A H V, Cooper J M
Abstract excerpt
Alpha synuclein protein may play an important role in familial and sporadic Parkinson's disease pathology. We have induced G209A mutant or wild-type alpha-synuclein expression in stable HEK293 cell models to determine if this influences markers of oxidative stress and damage under normal conditions or in the presence of dopamine or paraquat. Induced wild-type or mutant alpha-synuclein expression alone had no...
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