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Article

Molecular mechanisms underlying the flavonoid-induced inhibition of alpha-synuclein fibrillation.

Biochemistry - 1 Sept 2009

Meng Xiaoyun, Munishkina Larissa A, Fink Anthony L, Uversky Vladimir N

Abstract excerpt

The molecular mechanism underlying the flavonoid-induced inhibition of alpha-synuclein fibrillation was thoroughly examined by various biochemical and biophysical approaches. The noncovalent binding of the inhibitory flavonoids to alpha-synuclein and the covalent modification by the flavonoid quinone led to the restriction of the conformational changes in this natively unfolded protein and to the stabilization of...

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Identifiers

PMID: 19634918
DOI: 10.1021/bi900506b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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