Article

Suppression and modulation mechanism underlying the flavonoid-induced inhibition of fibrillation of α-synuclein

2025-08-25

Abstract excerpt

The accumulation of α-synuclein (αSyn) aggregates is a hallmark of synucleinopathies, including Parkinson’s disease (PD). However, the progression from harmless monomeric αSyn to misfolded oligomers and fibrillar species remains largely unclear. In this study, we examined the effect of Cyanidin, a naturally occurring neuroprotective compound, on the aggregation properties of α-syn using a combination of various bi...

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Literature Corpus work: 65189cd8-260e-517a-8549-8b17dd7ad3ff
DOI: 10.1101/2025.08.21.671593

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