Article
A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics - 1 Apr 2012
Prabhudesai Shubhangi, Sinha Sharmistha, Attar Aida, Kotagiri Aswani, Fitzmaurice Arthur G, Lakshmanan Rajeswari, Lakshmanan Ravi, Ivanova Magdalena I, Loo Joseph A, Klärner Frank-Gerrit, Schrader Thomas, Stahl Mark, Bitan Gal, Bronstein Jeff M
Abstract excerpt
Aggregation of α-synuclein (α-syn) is implicated as being causative in the pathogenesis of Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies. Despite several therapies that improve symptoms in these disorders, none slow disease progression. Recently, a novel "molecular tweezer" (MT) termed CLR01 has been described as a potent inhibitor of assembly and toxicity of multiple amyloidogenic...
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