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Article

Dissecting the mechanisms of tissue transglutaminase-induced cross-linking of alpha-synuclein: implications for the pathogenesis of Parkinson disease.

The Journal of biological chemistry - 8 May 2009

Schmid Adrien W, Chiappe Diego, Pignat Vérène, Grimminger Valerie, Hang Ivan, Moniatte Marc, Lashuel Hilal A

Abstract excerpt

Tissue transglutaminase (tTG) has been implicated in the pathogenesis of Parkinson disease (PD). However, exactly how tTG modulates the structural and functional properties of alpha-synuclein (alpha-syn) and contributes to the pathogenesis of PD remains unknown. Using site-directed mutagenesis co...

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Identifiers

PMID: 19164286
DOI: 10.1074/jbc.M809067200
PMCID: PMC2676045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19164286-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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