Article
Comparative assessment of the functional p53 status in glioma cells.
Anticancer research - 1 Jan 2000
Kim E L, Yoshizato K, Kluwe L, Meissner H, Warnecke G, Zapf S, Westphal M, Deppert W, Giese A
Abstract excerpt
BACKGROUND: p53 is the most frequently mutated gene in human cancers and its functional integrity is an important predictor of treatment response and clinical outcome. The majority of mutations found in different types of cancer cluster within the DNA binding domain encoded by exons 5-8. In clinical specimens the functional status of p53 is, therefore, often evaluated by direct mutation analysis of exons 5-8 or...
Topics
- Brain Neoplasms
- Cell Line, Tumor
- Cell Nucleus
- Electrophoresis
- Exons
- Genes, p53
- Glioma
- Humans
- Mutation
- Phosphorylation
- Subcellular Fractions
- Tumor Suppressor Protein p53