Article
Analysis of p53 gene mutations in human glioma cell lines.
Noshuyo byori = Brain tumor pathology - 1 Apr 1996
Koga H, Zhang S, Washiyama K, Ichikawa T, Onda K, Kumanishi T
Abstract excerpt
Seven human glioma cell lines were examined for mutations of the p53 gene and their mRNA and protein expressions. Five cell lines revealed a missense mutation at, codons 237, 245, or 273. Their p53 mRNA expression was variably distinct and not always comparable to p53 protein expression, suggesti...
Topics
- Brain Neoplasms
- Genes, Tumor Suppressor
- Genes, p53
- Glioma
- Humans
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- RNA, Messenger
- RNA, Neoplasm
- RNA, Ribosomal, 18S
- RNA, Ribosomal, 23S
- Tumor Cells, Cultured