Article
Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1993
Ullrich S J, Sakaguchi K, Lees-Miller S P, Fiscella M, Mercer W E, Anderson C W, Appella E
Abstract excerpt
The product of the p53 gene suppresses cell growth and plays a critical role in suppressing development of human tumors. p53 protein binds DNA, activates transcription, and can be phosphorylated at N- and C-terminal sites. Previously, wild-type p53 was shown to be hyperphosphorylated compared to mutant p53 during p53-mediated growth arrest in vivo. Here we show that Ser-15 and Ser-9 in the N-terminal...
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