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Article

Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein.

Molecular and cellular biology - 1 Jan 1991

Ginsberg D, Michael-Michalovitz D, Ginsberg D, Oren M

Abstract excerpt

A temperature-sensitive mutant of p53, p53Val-135, was found to be able to arrest cell proliferation when overexpressed at 32.5 degrees C. While much of the protein was cytoplasmic in cells proliferating at 37.5 degrees C, it became predominantly nuclear at 32.5 degrees C. Concomitantly, p53Val-1...

Topics

Animals
Cell Compartmentation
Cell Division
Cell Nucleus
Cell Transformation, Neoplastic
Fluorescent Antibody Technique
In Vitro Techniques
Mice
Mutation
Temperature
Tumor Suppressor Protein p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1986251
DOI: 10.1128/mcb.11.1.582-585.1991
PMCID: PMC359675

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1986251-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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