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Article

The diversity of p53 mutations among human brain tumors and their functional consequences.

Neurochemistry international - 1 Jun 2002

Zupanska Agata, Kaminska Bozena

Abstract excerpt

The p53 tumor suppressor is implicated in cell cycle control, DNA repair, replicative senescence and programmed cell death. Inactivation of the p53 contributes to the wide range of human tumors, including glial neoplasms. In this review, we describe the regulation and biochemical properties of p53 protein that may explain its ability to activate various genetic programs underlying cellular responses to stress...

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PMID: 11900859
DOI: 10.1016/s0197-0186(01)00114-0

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