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Article

Accumulation of mutant p53 and hsp72 by heat treatment, and their association in a human glioblastoma cell line.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group - 1 Jan 2000

Ohnishi T, Matsumoto H, Takahashi A, Shimura M, Majima H J

Abstract excerpt

The cellular content of mutant p53 and hsp72 proteins following gamma-ray irradiation, UV irradiation, and heat treatment was studied in A-7 cells, a human glioblastoma cell line. A-7 was found to contain a mutant p53 gene in which the arginine codon at position 175 was substituted by a histidine codon. Although the p53 gene was mutant, the phenotype of the p53 protein appeared wild-type since the cellular...

Topics

Gamma Rays
Genes, p53
Glioblastoma
HSP72 Heat-Shock Proteins
Heat-Shock Proteins
Hot Temperature
Humans
Hyperthermia, Induced
Mutation
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Suppressor Protein p53

Ultraviolet Rays

Source

Identifiers

PMID: 7594817
DOI: 10.3109/02656739509022498

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7594817-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Accumulation of mutant p53 and hsp72 by heat treatment, and their association in a human glioblastoma cell line.PMID 7594817Read ↗

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