Article
Molecular analysis of mutations in thyroid tumors with TGGE.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 1 Jan 1995
Simon D, Goretzki P E, Schäfer C, Gorelov V, Ebeling B, Röher H D
Abstract excerpt
Immunohistochemical demonstration of overexpression of the p53 protein indicates a mutational alteration of the gene. Our own investigations of 59 differentiated thyroid carcinomas revealed an overexpression in 15% of the tumors. A correlation to unfavourable tumor prognosis was found (stage I an...
Topics
- Adenocarcinoma, Follicular
- Base Sequence
- Carcinoma, Medullary
- Carcinoma, Papillary
- Electrophoresis, Polyacrylamide Gel
- Exons
- Humans
- Molecular Probes
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Temperature
- Thyroid Neoplasms
- Thyroid Nodule