The p53 gene and protein in human brain tumors.

Abstract excerpt

p53 mutation is most likely an integral early step in the formation of a subset of human diffuse, fibrillary astrocytomas, but is not a frequent event in other studied brain tumors. In astrocytomas, p53 mutations are clustered in the conserved regions of the gene and are predominantly single base pair transitions, frequently at CpG dinucleotides. These mutations result in mutant or truncated p53 proteins that...

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