The p53 gene and protein in human brain tumors.

Abstract excerpt

p53 mutation is most likely an integral early step in the formation of a subset of human diffuse, fibrillary astrocytomas, but is not a frequent event in other studied brain tumors. In astrocytomas, p53 mutations are clustered in the conserved regions of the gene and are predominantly single base...

Topics

• Astrocytoma
• Base Sequence
• Brain Neoplasms
• Chromosomes, Human, Pair 17
• Dinucleoside Phosphates
• Genes, p53
• Humans
• Mutation
• Tumor Suppressor Protein p53