Article
The p53 gene and its role in human brain tumors.
Glia - 1 Nov 1995
Bögler O, Huang H J, Kleihues P, Cavenee W K
Abstract excerpt
Mutation of the p53 gene is among the most common lesions in a variety of human tumors, including those of the central nervous system. In most instances, mutation of one p53 allele is followed by loss of the remaining wild-type allele, resulting in cells with a complete absence of functional wild...
Topics
- Amino Acid Sequence
- Brain Neoplasms
- Cell Death
- Cell Division
- DNA Damage
- Genes, p53
- Germ-Line Mutation
- Glioma
- Humans
- Molecular Sequence Data
- Mutation
- Transcription, Genetic
- Tumor Suppressor Protein p53