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Article

The TBX21 transcription factor T-1993C polymorphism is associated with decreased IFN-γ and IL-4 production by primary human lymphocytes.

Human immunology - 1 Jun 2012

Fyall K M, Fong A M, Rao S B, Ibrahim J G, Waxweiler W T, Thomas N E

Abstract excerpt

T-bet is a transcription factor that drives the Th1 immune response primarily through promoting expression of the IFN-γ gene. Polymorphisms in the T-bet gene, TBX21, have been associated with immune-mediated diseases such as asthma and systemic sclerosis. We found that the TBX21 promoter polymorphism T-1993C is associated with a significant decrease in IL-4 and IFN-γ production by stimulated primary human...

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Source

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Identifiers

PMID: 22521571
DOI: 10.1016/j.humimm.2012.03.005
PMCID: PMC3368090

Genes

TBX21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The TBX21 transcription factor T-1993C polymorphism is associated with decreased IFN-γ and IL-4 production by primary human lymphocytes.PMID 22521571Read ↗

A common promoter variant of TBX21 is associated with allele specific binding to Yin-Yang 1 and reduced gene expression.Semantic proximity Read ↗

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