Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of TBX21 promoter polymorphisms with type 1 autoimmune hepatitis in a Chinese population.

Human immunology - 1 Jan 2011

Chen Song, Zhao Wenli, Tan Wenting, Luo Xiao, Dan Yunjie, You Zhonglan, Kuang Xuemei, Wang Yuming, Deng Guohong

Abstract excerpt

The T-box transcription factor T-bet is a key regulator for the lineage commitment in CD4 Th1 cells and CD8 T cells by activating the hallmark production of interferon-γ, and its expression level is linked to autoimmune diseases. T-1993C and T-1514C polymorphisms in the TBX21 gene (encoding T-bet) promoter can affect transcription activity. We investigated the distributions of these functional polymorphisms in 84...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to T-bet Transcription Factor
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis, Autoimmune

Share to Promoter Regions, Genetic

Share to Survival Analysis

Share to T-Box Domain Proteins

Share to Th1 Cells

Source

Identifiers

PMID: 20977921
DOI: 10.1016/j.humimm.2010.10.019

Genes

TBX21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of TBX21 promoter polymorphisms with type 1 autoimmune hepatitis in a Chinese population.PMID 20977921Read ↗

Influence of TBX21 T-1993C variant on autoimmune hepatitis development by Yin-Yang 1 binding.Semantic proximity Read ↗

A common promoter variant of TBX21 is associated with allele specific binding to Yin-Yang 1 and reduced gene expression.Semantic proximity Read ↗

Association of TBX21 gene haplotypes in a Chinese population with systemic lupus erythematosus.Semantic proximity Read ↗

Association analysis of hepatitis virus B infection with haplotypes of the TBX21 gene promoter region in the Chinese population.Semantic proximity Read ↗

Association of TBX21 polymorphisms in a Korean population with rheumatoid arthritis.Semantic proximity Read ↗

Evidence for genetic association of TBX21 and IFNG with systemic lupus erythematosus in a Chinese Han population.Semantic proximity Read ↗

Association of the rs17250932, rs4794067, and rs2240017 polymorphism in the TBX21 gene with autoimmune diseases: A meta-analysis.Semantic proximity Read ↗

The TBX21 transcription factor T-1993C polymorphism is associated with decreased IFN-γ and IL-4 production by primary human lymphocytes.Semantic proximity Read ↗

The polymorphisms of T cell-specific TBX21 gene may contribute to the susceptibility of chronic immune thrombocytopenia in Chinese population.Semantic proximity Read ↗

Association between the genetic variations within TBX21 gene promoter and the clinicopathological characteristics of esophageal squamous cell carcinoma in a high-risk Chinese population.Semantic proximity Read ↗

The polymorphisms of T cell-specific TBX21 and STAT4 genes may contribute to the susceptibility of Chinese individuals to aplastic anemia.Semantic proximity Read ↗

Association of a single nucleotide polymorphism in TNIP1 with type-1 autoimmune hepatitis in the Japanese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.