Article
Linkage and microarray analyses of susceptibility genes in ACI/Seg rats: a model for prostate cancers in the aged.
Cancer research - 1 Apr 2005
Yamashita Satoshi, Suzuki Shugo, Nomoto Tomoko, Kondo Yasushi, Wakazono Kuniko, Tsujino Yoshimi, Sugimura Takashi, Shirai Tomoyuki, Homma Yukio, Ushijima Toshikazu
Abstract excerpt
ACI/Seg (ACI) rats develop prostate cancers spontaneously with aging, similar to humans. Here, to identify genes involved in prostate cancer susceptibility, we did linkage analysis and oligonucleotide microarray analysis. Linkage analysis was done using 118 effective rats, and prostate cancer susceptibility 1 (Pcs1), whose ACI allele dominantly induced prostate cancers, was mapped on chromosome 19 [logarithm of...
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