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Article

Mapping of three genetic determinants of susceptibility to estrogen-induced mammary cancer within the Emca8 locus on rat chromosome 5.

Cancer prevention research (Philadelphia, Pa.) - 1 Jan 2013

Schaffer Beverly S, Leland-Wavrin Kristin M, Kurz Scott G, Colletti John A, Seiler Nicole L, Warren Christopher L, Shull James D

Abstract excerpt

The ACI rat model of 17β-estradiol (E2)-induced mammary cancer has gained wide use in the study of breast cancer etiology, prevention, and genetics. Emca8, a QTL that determines susceptibility to E2-induced mammary cancer, was previously mapped to rat chromosome 5 (RNO5) in an intercross between resistant Brown Norway (BN) and susceptible ACI rats. In this study, a panel of congenic rat strains, each of which...

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Identifiers

PMID: 23151807
DOI: 10.1158/1940-6207.CAPR-12-0346-T
PMCID: PMC3536887

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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