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Article

Genetic bases of estrogen-induced tumorigenesis in the rat: mapping of loci controlling susceptibility to mammary cancer in a Brown Norway x ACI intercross.

Cancer research - 1 Aug 2006

Schaffer Beverly S, Lachel Cynthia M, Pennington Karen L, Murrin Clare R, Strecker Tracy E, Tochacek Martin, Gould Karen A, Meza Jane L, McComb Rodney D, Shull James D

Abstract excerpt

Exposure to estrogens is associated with an increased risk of breast cancer. Our laboratory has shown that the ACI rat is uniquely susceptible to 17beta-estradiol (E2)-induced mammary cancer. We previously mapped two loci, Emca1 and Emca2 (estrogen-induced mammary cancer), that act independently to determine susceptibility to E2-induced mammary cancer in crosses between the susceptible ACI rat strain and the...

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Source

Identifiers

PMID: 16885383
DOI: 10.1158/0008-5472.CAN-06-0143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic bases of estrogen-induced tumorigenesis in the rat: mapping of loci controlling susceptibility to mammary cancer in a Brown Norway x ACI intercross.PMID 16885383Read ↗

Validation of six genetic determinants of susceptibility to estrogen-induced mammary cancer in the rat and assessment of their relevance to breast cancer risk in humans.Semantic proximity Read ↗

Genetic determination of susceptibility to estrogen-induced mammary cancer in the ACI rat: mapping of Emca1 and Emca2 to chromosomes 5 and 18.Semantic proximity Read ↗

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Development and characterization of a novel rat model of estrogen-induced mammary cancer.Semantic proximity Read ↗

Rat models of 17β-estradiol-induced mammary cancer reveal novel insights into breast cancer etiology and prevention.Semantic proximity Read ↗

Genetic control of estrogen action in the rat: mapping of QTLs that impact pituitary lactotroph hyperplasia in a BN x ACI intercross.Semantic proximity Read ↗

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The rat oncogenome: comparative genetics and genomics of rat models of mammary carcinogenesis.Semantic proximity Read ↗

Genetic bases of estrogen-induced pituitary tumorigenesis: identification of genetic loci determining estrogen-induced pituitary growth in reciprocal crosses between the ACI and Copenhagen rat strains.Semantic proximity Read ↗

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