Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4.

Abstract excerpt

Early developmental perturbations have been linked to adult-onset prostate pathology, including excessive exposure to estrogenic compounds; however, the molecular basis for this imprinting event is not known. An important and controversial health concern is whether low-dose exposures to hormonally active environmental estrogens, such as bisphenol A, can promote human diseases, including prostate cancer. Here, we...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to 3',5'-Cyclic-AMP Phosphodiesterases
• Share to Benzhydryl Compounds