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Article

Development and characterization of a novel rat model of estrogen-induced mammary cancer.

Endocrine-related cancer - 1 Apr 2015

Dennison Kirsten L, Samanas Nyssa Becker, Harenda Quincy Eckert, Hickman Maureen Peters, Seiler Nicole L, Ding Lina, Shull James D

Abstract excerpt

The ACI rat model of 17β-estradiol (E2)-induced mammary cancer is highly relevant for use in establishing the endocrine, genetic, and environmental bases of breast cancer etiology and identifying novel agents and strategies for preventing breast cancer. E2 treatment rapidly induces mammary cancer in female ACI rats and simultaneously induces pituitary lactotroph hyperplasia and adenoma. The pituitary tumors can...

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Identifiers

PMID: 25800038
DOI: 10.1530/ERC-14-0539
PMCID: PMC4372900

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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