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Article

Genetic determination of susceptibility to estrogen-induced mammary cancer in the ACI rat: mapping of Emca1 and Emca2 to chromosomes 5 and 18.

Genetics - 1 Dec 2004

Gould Karen A, Tochacek Martin, Schaffer Beverly S, Reindl Tanya M, Murrin Clare R, Lachel Cynthia M, VanderWoude Eric A, Pennington Karen L, Flood Lisa A, Bynote Kimberly K, Meza Jane L, Newton Michael A, Shull James D

Abstract excerpt

Hormonal, genetic, and environmental factors play major roles in the complex etiology of breast cancer. When treated continuously with 17beta-estradiol (E2), the ACI rat exhibits a genetically conferred propensity to develop mammary cancer. The susceptibility of the ACI rat to E2-induced mammary cancer appears to segregate as an incompletely dominant trait in crosses to the resistant Copenhagen (COP) strain. In...

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Identifiers

PMID: 15611180
DOI: 10.1534/genetics.104.033878
PMCID: PMC1448731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic determination of susceptibility to estrogen-induced mammary cancer in the ACI rat: mapping of Emca1 and Emca2 to chromosomes 5 and 18.PMID 15611180Read ↗

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