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Genetic analysis of the susceptibility in rats to aberrant crypt foci formation by 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine, PhIP.

Cancer letters - 1 Sept 1999

Nakagama H, Souda K, Ochiai M, Ishiguro Y, Sugimura T, Nagao M

Abstract excerpt

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), the most abundant heterocyclic amine produced while cooking fish and meat, induces aberrant crypt foci (ACF) and colon cancers in rats. We previously reported that F344 rats were sensitive and ACI rats resistant to ACF formation by PhIP, and that the genetic susceptibility in F344 rats to ACF formation by PhIP was autosomally dominant over ACI rats. To...

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PMID: 10503905
DOI: 10.1016/s0304-3835(99)00126-3

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