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Article

Expression, Function of the Human Androgen-Responsive Gene AD11 in Prostate Cancer

1 Aug 2007

Abstract excerpt

We have previously identified an androgen-responsive gene in rat prostate that shares homology with the aci-reductone dioxygenase (ARD/ARD') family of metal-binding enzymes involved in methionine salvage. We found that the gene, aci-reductone dioxygenase 1 (ADI1), was downregulated in prostate cancer cells, whereas enforced expression of rat Adi1 in these cells caused apoptosis. Here we report the...

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PMID: 17786183
DOI: 10.1593/neo.07415

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