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Identification and chromosome mapping of loci predisposing to colorectal cancer that control Wnt/beta-catenin pathway and progression of early lesions in the rat.

Carcinogenesis - 1 Nov 2007

De Miglio Maria R, Virdis Patrizia, Calvisi Diego F, Mele Daniela, Muroni Maria R, Frau Maddalena, Pinna Federico, Tomasi Maria L, Simile Maria M, Pascale Rosa M, Feo Francesco

Abstract excerpt

Sporadic colorectal cancer (CRC) is a major health concern worldwide. Epidemiologic evidence suggests a polygenic predisposition to CRC, but the genes responsible remain unknown. Here, we performed genome-wide scanning of male (ACI/SegHsd x Wistar-Furth)F2 (AWF2) rats to map susceptibility genes influencing the evolution of early colorectal lesions to adenocarcinoma following 1,2-dimethylhydrazine administration....

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PMID: 17510081
DOI: 10.1093/carcin/bgm119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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