Article
Validation of six genetic determinants of susceptibility to estrogen-induced mammary cancer in the rat and assessment of their relevance to breast cancer risk in humans.
G3 (Bethesda, Md.) - 28 May 2014
Colletti John A, Leland-Wavrin Kristin M, Kurz Scott G, Hickman Maureen Peters, Seiler Nicole L, Samanas Nyssa Becker, Eckert Quincy A, Dennison Kirsten L, Ding Lina, Schaffer Beverly S, Shull James D
Abstract excerpt
When treated with 17β-estradiol, female ACI rats (Rattus norvegicus) rapidly develop mammary cancers that share multiple phenotypes with luminal breast cancers. Seven distinct quantitative trait loci that harbor genetic determinants of susceptibility to 17β-estradiol-induced mammary cancer have been mapped in reciprocal intercrosses between susceptible ACI rats and resistant Brown Norway (BN) rats. A panel of...
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