Article
Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype.
The Journal of cell biology - 1 Jan 1996
Erlebacher A, Derynck R
Abstract excerpt
The development of the skeleton requires the coordinated activities of bone-forming osteoblasts and bone-resorbing osteoclasts. The activities of these two cell types are likely to be regulated by TGF-beta, which is abundant in bone matrix. We have used transgenic mice to evaluate the role of TGF...
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