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Article

Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling.

The Journal of biological chemistry - 25 Jun 2004

Mishina Yuji, Starbuck Michael W, Gentile Michael A, Fukuda Tomokazu, Kasparcova Viera, Seedor J Gregory, Hanks Mark C, Amling Michael, Pinero Gerald J, Harada Shun-ichi, Behringer Richard R

Abstract excerpt

Bone morphogenetic proteins (BMPs) function during various aspects of embryonic development including skeletogenesis. However, their biological functions after birth are less understood. To investigate the role of BMPs during bone remodeling, we generated a postnatal osteoblast-specific disruption of Bmpr1a that encodes the type IA receptor for BMPs in mice. Mutant mice were smaller than controls up to 6 months...

Read the complete abstract on PubMed

Topics

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Share to Bone Development
Share to Bone Morphogenetic Protein Receptors, Type I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Remodeling

Share to Bone Resorption

Share to Calcification, Physiologic

Share to Osteoclasts

Share to Ovariectomy

Share to Receptors, Growth Factor

Source

Identifiers

PMID: 15090551
DOI: 10.1074/jbc.M404222200

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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