Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation

10 Jun 2002

Abstract excerpt

Functions of bone morphogenetic proteins (BMPs) are initiated by signaling through specific type I and type II serine/threonine kinase receptors. In previous studies, we have demonstrated that the type IB BMP receptor (BMPR-IB) plays an essential and specific role in osteoblast commitment and differentiation. To determine the role of BMP receptor signaling in bone formation in vivo, we generated transgenic mice,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Dental Protein Studies
Share to Bone health and treatments
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12058020
DOI: 10.1083/jcb.200109012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formationPMID 12058020Read ↗

Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling.Semantic proximity Read ↗

Deletion of BMP receptor type IB decreased bone mass in association with compromised osteoblastic differentiation of bone marrow mesenchymal progenitors.Semantic proximity Read ↗

Bone Morphogenetic Protein (BMP) signaling in development and human diseasesSemantic proximity Read ↗

Overexpression of BMP3 in the developing skeleton alters endochondral bone formation resulting in spontaneous rib fracturesSemantic proximity Read ↗

Increased BMP-Smad signaling does not affect net bone mass in long bonesSemantic proximity Read ↗

Genetically modified animal models as tools for studying bone and mineral metabolism.Semantic proximity Read ↗

Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype.Semantic proximity Read ↗

Loss of BMP signaling mediated by BMPR1A in osteoblasts leads to differential bone phenotypes in mice depending on anatomical location of the bones.Semantic proximity Read ↗

Inducible Activation of FGFR2 in Adult Mice Promotes Bone Formation After Bone Marrow Ablation.Semantic proximity Read ↗

Tgfbr2 is required in osterix expressing cells for postnatal skeletal development.Semantic proximity Read ↗

Skeletal overexpression of gremlin impairs bone formation and causes osteopenia.Semantic proximity Read ↗

Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.