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Article

Osteocyte Wnt/β-Catenin Signaling Is Required for Normal Bone Homeostasis

19 Apr 2010

Abstract excerpt

Beta-Catenin-dependent canonical Wnt signaling plays an important role in bone metabolism by controlling differentiation of bone-forming osteoblasts and bone-resorbing osteoclasts. To investigate its function in osteocytes, the cell type constituting the majority of bone cells, we generated osteocyte-specific beta-catenin-deficient mice (Ctnnb1(loxP/loxP); Dmp1-Cre). Homozygous mutants were born at normal...

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PMID: 20404086
DOI: 10.1128/mcb.01428-09

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