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Article

Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition.

PloS one - 1 Jan 2013

Riddle Ryan C, Diegel Cassandra R, Leslie Julie M, Van Koevering Kyle K, Faugere Marie-Claude, Clemens Thomas L, Williams Bart O

Abstract excerpt

The canonical Wnt signaling pathway is critical for skeletal development and maintenance, but the precise roles of the individual Wnt co-receptors, Lrp5 and Lrp6, that enable Wnt signals to be transmitted in osteoblasts remain controversial. In these studies, we used Cre-loxP recombination, in which Cre-expression is driven by the human osteocalcin promoter, to determine the individual contributions of Lrp5 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Low Density Lipoprotein Receptor-Related Protein-5

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Source

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Identifiers

PMID: 23675479
DOI: 10.1371/journal.pone.0063323
PMCID: PMC3651091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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