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Article

Deletion of BMP receptor type IB decreased bone mass in association with compromised osteoblastic differentiation of bone marrow mesenchymal progenitors.

Scientific reports - 6 Apr 2016

Shi Ce, Iura Ayaka, Terajima Masahiko, Liu Fei, Lyons Karen, Pan Haichun, Zhang Honghao, Yamauchi Mitsuo, Mishina Yuji, Sun Hongchen

Abstract excerpt

We previously found that disruption of two type I BMP receptors, Bmpr1a and Acvr1, respectively, in an osteoblast-specific manner, increased bone mass in mice. BMPR1B, another BMP type I receptor, is also capable of binding to BMP ligands and transduce BMP signaling. However, little is known about the function of BMPR1B in bone. In this study, we investigated the bone phenotype in Bmpr1b null mice and the impacts...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27048979
DOI: 10.1038/srep24256
PMCID: PMC4822175

Genes

ACVR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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