Article
Functionally significant insulin-like growth factor I receptor mutations in centenarians.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2008
Suh Yousin, Atzmon Gil, Cho Mi-Ook, Hwang David, Liu Bingrong, Leahy Daniel J, Barzilai Nir, Cohen Pinchas
Abstract excerpt
Rather than being a passive, haphazard process of wear and tear, lifespan can be modulated actively by components of the insulin/insulin-like growth factor I (IGFI) pathway in laboratory animals. Complete or partial loss-of-function mutations in genes encoding components of the insulin/IGFI pathway result in extension of life span in yeasts, worms, flies, and mice. This remarkable conservation throughout...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.