Article
Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control.
The Journal of clinical endocrinology and metabolism - 1 Jul 2003
Bonafè Massimiliano, Barbieri Michelangela, Marchegiani Francesca, Olivieri Fabiola, Ragno Emilia, Giampieri Claudia, Mugianesi Elena, Centurelli Matteo, Franceschi Claudio, Paolisso Giuseppe
Abstract excerpt
Current literature indicates that abrogation of the IGF-I response pathway affects longevity in Caenorhabditis elegans, and that the down-regulation of IGF-I gene expression is associated with an extension of the life span in mice. In this paper we tested the hypothesis that polymorphic variants of IGF-I response pathway genes, namely IGF-IR (IGF-I receptor; G/A, codon 1013), PI3KCB (phosphoinositol 3-kinase;...
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