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Article

Single-gene mutations and healthy ageing in mammals.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 12 Jan 2011

Bartke Andrzej

Abstract excerpt

Studies of the effects of single-gene mutations on longevity in Caenorhabditis elegans, Drosophila melanogaster and Mus musculus identified homologous, highly conserved signalling pathways that influence ageing. In each of these very distantly related species, single mutations which lead-directly or indirectly-to reduced insulin, insulin-like growth factor (IGF) or insulin/IGF-like signalling (IIS) can produce...

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Identifiers

PMID: 21115527
DOI: 10.1098/rstb.2010.0281
PMCID: PMC3001310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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