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Insulin-like growth factors and aging: lessons from Laron syndrome

24 Oct 2023

Abstract excerpt

The growth hormone (GH)-insulin-like growth factor-1 (IGF1) signaling pathway emerged in recent years as a key determinant of aging and longevity. Disruption of this network in different animal species, including flies, nematodes and mouse, was consistently associated with an extended lifespan. Epidemiological analyses have shown that patients with Laron syndrome (LS), the best-characterized disease under the...

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PMID: 37941907
DOI: 10.3389/fendo.2023.1291812

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