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Article

The insulin/IGF-1 signaling in mammals and its relevance to human longevity.

Experimental gerontology - 1 Nov 2005

Rincon Marielisa, Rudin Eric, Barzilai Nir

Abstract excerpt

Hormones, like insulin and insulin-like growth factor 1 (IGF-1), are thought to be deeply involved with longevity. Lower species have been the source for most of our current knowledge on the role of the insulin/IGF-1 signaling in modulating lifespan. This hormonal system may have originated from a very early common ancestor and is involved in many functions that are necessary for metabolism, growth, and fertility...

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Identifiers

PMID: 16168602
DOI: 10.1016/j.exger.2005.06.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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