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Article

Reduced initiation frequency from oriC restores viability of a temperature-sensitive Escherichia coli replisome mutant.

Microbiology (Reading, England) - 1 Mar 2005

Skovgaard Ole, Løbner-Olesen Anders

Abstract excerpt

The dnaX gene of Escherichia coli encodes tau and gamma clamp loader subunits of the replisome. Cells carrying the temperature-sensitive dnaX2016 mutation were induced for the SOS response at non-permissive temperature. The SOS induction most likely resulted from extensive replication fork collapse that exceeded the cells' capacity for restart. Seven mutations in the dnaA gene that partly suppressed the dnaX2016...

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Identifiers

PMID: 15758241
DOI: 10.1099/mic.0.27630-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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