Mutations in Escherichia coli dnaA which suppress a dnaX(Ts) polymerization mutation and are dominant when located in the chromosomal allele and recessive on plasmids.

Abstract excerpt

Extragenic suppressor mutations which had the ability to suppress a dnaX2016(Ts) DNA polymerization defect and which concomitantly caused cold sensitivity have been characterized within the dnaA initiation gene. When these alleles (designated Cs, Sx) were moved into dnaX+ strains, the new mutants became cold sensitive and phenotypically were initiation defective at 20 degrees C (J.R. Walker, J.A. Ramsey, and W.G....

Topics

• Alleles
• Amino Acid Sequence
• Bacterial Proteins
• Base Sequence
• Chromosome Mapping
• DNA Polymerase III
• DNA-Binding Proteins
• Genes, Dominant
• Genes, Recessive
• Genes, Suppressor
• Molecular Sequence Data