Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of temperature-sensitive chromosome replication of an Escherichia coli dnaX(Ts) mutant by reduction of initiation efficiency.

Journal of bacteriology - 1 Jun 2003

Blinkova Alexandra, Hermandson Mary Jo, Walker James R

Abstract excerpt

Temperature sensitivity of DNA polymerization and growth of a dnaX(Ts) mutant is suppressible at 39 to 40 degrees C by mutations in the initiator gene, dnaA. These suppressor mutations concomitantly cause initiation inhibition at 20 degrees C and have been designated Cs,Sx to indicate both phenotypic characteristics of cold-sensitive initiation and suppression of dnaX(Ts). One dnaA(Cs,Sx) mutant, A213D, has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Bacterial
Share to Culture Media

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Polymerase III

Share to DNA Replication

Share to Gene Expression Regulation, Bacterial

Share to Genes, Suppressor

Share to Glucose

Share to Temperature

Source

Open in PubMed Open full text

Identifiers

PMID: 12775696
DOI: 10.1128/JB.185.12.3583-3595.2003
PMCID: PMC156227

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of temperature-sensitive chromosome replication of an Escherichia coli dnaX(Ts) mutant by reduction of initiation efficiency.PMID 12775696Read ↗

Mutations in Escherichia coli dnaA which suppress a dnaX(Ts) polymerization mutation and are dominant when located in the chromosomal allele and recessive on plasmids.Semantic proximity Read ↗

Defective initiation in an Escherichia coli dnaA(Cs,Sx) mutant.Semantic proximity Read ↗

Reduced initiation frequency from oriC restores viability of a temperature-sensitive Escherichia coli replisome mutant.Semantic proximity Read ↗

Escherichia coli DnaA protein: specific biochemical defects of mutant DnaAs reduce initiation frequency to suppress a temperature-sensitive dnaX mutation.Semantic proximity Read ↗

A novel class of mutations that affect DNA replication in E. coli.Semantic proximity Read ↗

SeqA limits DnaA activity in replication from oriC in Escherichia coli.Semantic proximity Read ↗

A role for nonessential domain II of initiator protein, DnaA, in replication control.Semantic proximity Read ↗

Initiation of chromosomal DNA replication which is stimulated without oversupply of DnaA protein in Escherichia coli.Semantic proximity Read ↗

Autoregulation of the Escherichia coli replication initiator protein, DnaA, is indirect.Semantic proximity Read ↗

Hyperactive initiation of chromosomal replication in vivo and in vitro by a mutant initiator protein, DnaAcos, of Escherichia coli.Semantic proximity Read ↗

Cell death in Escherichia coli dnaE(Ts) mutants incubated at a nonpermissive temperature is prevented by mutation in the cydA gene.Semantic proximity Read ↗

A comprehensive set of DnaA-box mutations in the replication origin, oriC, of Escherichia coli.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.